A Study to Evaluate Investigational Agents With or Without Pembrolizumab (MK-3475) in Participants With Advanced Esophageal Cancer Previously Exposed to Programmed Cell Death 1 Protein (PD-1)/ Programmed Cell Death Ligand 1 (PD-L1) Treatment (MK-3475-06B)
报名条件（概要）
- 年龄：18 Years – 不限
- 性别：不限
- 健康志愿者：不接受
完整入排标准请以官方页面为准。
开展国家/地区
United States、Brazil、Chile、China、Germany、Italy、Japan、Norway、Singapore、South Korea、Switzerland、Taiwan
药品与企业信息
80-100 mg/m\^2 IV infusion, administered on days 1, 8, and 15 of every 28-day cycle.
180 mg/m\^2 IV infusion, administered on day 1 of every 14-day cycle.
其他名称：MK-3475、KEYTRUDA®
200 mg IV infusion, administered every Q3W up to 35 infusions.
其他名称：anti-immunoglobulin-like transcript 4 (anti-ILT4)
800 mg IV infusion, administered Q3W up to 35 infusions.
其他名称：SKB264、MK-2870、sac-TMT
4 mg/kg or 5 mg/kg IV infusion on Days 1, 15, and 29 of each 42-day cycle.
Administered per product label.
Administered per product label.
研发企业
试验官方登记的主要申办方；研究机构申办时会显示相应机构名称。
生产企业
Paclitaxel
Teva Pharmaceuticals, Inc.
研发企业与生产企业可能不是同一家。研究阶段药品可能尚未公布生产企业；生产企业仅取自美国上市原研药说明书所列企业（不含仿制药），不作推测；仅在其他国家上市的药品暂无法显示。
研究简介（原文）
This is a Phase 1/2, multicenter, randomized, open-label umbrella platform study to evaluate the safety and efficacy of investigational agents with or without pembrolizumab and/or chemotherapy, for the treatment of participants with second line (2L) esophageal squamous cell carcinoma (ESCC) who have previously been exposed to PD-1/PD-L1 based treatment.
适应症
主动联系研究团队
总联系人（申办方／研究总部）
- Toll Free NumberTrialsites@msd.com1-888-577-8839
中国／港澳台研究中心
- Anhui Provincial Hospital ( Site 3501)Hefei，Anhui，China
- Beijing Cancer hospital-Digestive Oncology ( Site 3500)Beijing，Beijing Municipality，China
- The First Affiliated Hospital of Xiamen University ( Site 3516)Xiamen，Fujian，China
- The First Affiliated Hospital of Xinxiang Medical University-Oncology ( Site 3510)Xinxiang，Henan，China
- Henan Cancer Hospital ( Site 3518)Zhengzhou，Henan，China
- First Huai'an Hospital Affiliated to Nanjing Medical University ( Site 3506)Huai'an，Jiangsu，China
问自己是否符合条件、如何预筛
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英文版（发给研究团队）
Dear Study Team, I am a patient in China and I am interested in participating in your clinical trial: Study Title: A Study to Evaluate Investigational Agents With or Without Pembrolizumab (MK-3475) in Participants With Advanced Esophageal Cancer Previously Exposed to Programmed Cell Death 1 Protein (PD-1)/ Programmed Cell Death Ligand 1 (PD-L1) Treatment (MK-3475-06B) ClinicalTrials.gov Identifier: NCT05319730 Sponsor: Merck Sharp & Dohme LLC Investigational product: Paclitaxel, Irinotecan, Pembrolizumab, MK-4830, Lenvatinib About me: - Age: (please fill in) - Sex: (please fill in) - Confirmed diagnosis and stage: (please fill in) - Biomarkers / genetic testing: not available - Prior and current treatments: (please fill in) - Performance status (ECOG): not assessed - Current location: China - Travel ability: (please fill in) Could you please let me know: 1. Whether I might be eligible for this study; 2. Which site would be closest and most practical for me, and whether remote pre-screening is possible; 3. What documents (medical records, pathology or imaging reports, recent labs) I should prepare for pre-screening. I can provide English translations of my medical records. Thank you very much for your time and help. Kind regards, (your name) (your email / phone with country code)
中文对照（供您核对）
尊敬的研究团队： 我是一位来自中国的患者，希望咨询参加以下临床试验的可能： 研究名称：A Study to Evaluate Investigational Agents With or Without Pembrolizumab (MK-3475) in Participants With Advanced Esophageal Cancer Previously Exposed to Programmed Cell Death 1 Protein (PD-1)/ Programmed Cell Death Ligand 1 (PD-L1) Treatment (MK-3475-06B) 试验编号：NCT05319730 申办方：Merck Sharp & Dohme LLC 研究药物：Paclitaxel、Irinotecan、Pembrolizumab、MK-4830、Lenvatinib 我的基本情况： - 年龄：（请填写） - 性别：（请填写） - 确诊疾病与分期：（请填写） - 基因／标志物检测：暂无 - 既往及当前治疗：（请填写） - 体能状态（ECOG）：未评估 - 目前所在城市：中国 - 可前往范围：（请填写） 想请教三个问题： 1. 我是否可能符合本研究的入组标准？ 2. 哪个中心对我最方便可行？能否远程预筛？ 3. 预筛需要准备哪些资料（病历、病理、影像、近期化验）？ 我可以提供英文翻译版病历。感谢您的时间与帮助。 顺祝安康 （您的姓名） （您的邮箱／带国际区号的电话）
提示：请与主治医生一起发信——由医生署名的申请，回复率远高于患者单独发信。首封邮件不要附身份证号等敏感信息。研究团队通常在 3–10 个工作日内回复，两周无回音可礼貌追问一次。
下一步怎么做？
- 把本页信息带给您的主治医生，评估是否适合参加。
- 点击下方按钮打开官方注册页，查看研究中心联系方式。
- 直接联系研究团队咨询报名事宜（通常有中文同声翻译服务可协助沟通）。